We report two cases of successful treatment of thyroid cystic nodules using Viscum Album extract as a sclerotherapy material. Both cases showed volume reduction of more than 50%, and it is possible that a higher dose injection resulted in a larger volume reduction. In terms of side effects, pain, hematoma, and dyspnea, which can occur in sclerotherapy, were not observed. Since sclerotherapy is a procedure that can be performed repeatedly, we expect that the procedure can be performed with less concern in terms of side effects, and there is a possibility as another alternative material that can be used for sclerotherapy.