Based on the principles of the selective photothermolysis theory, pico second lasers can enhance the therapeutic effect on the target tissue and minimize damage to the surrounding tissue. Therefore, picosecond lasers have significant advantages over conventional laser techniques in terms of effectiveness, safety, and therapeutic effect on the pigmented skin. Additionally, picosecond lasers induce intraepidermal and dermal vacuole formation through laser-induced optical breakdown, which is associated with dermal remodeling by increasing dermal collagen and elastin formation. Based on these additional findings, picosecond lasers are reportedly effective in treating non-pigmented disorders, scars, and in cutaneous rejuvenation. Herein, we review the literature on the treatment of non-pigmented disorders by a picosecond laser and confirm its efficacy.