Purpose: This study aims to determine the influence of clinical nurses’ second-victim experience and second-victim support on their negative work-related outcomes. Methods: We used a cross-sectional design with a convenience sample of 179 clinical nurses from two Korean tertiary hospitals. The data were collected through a structured self-questionnaire survey and analyzed via descriptive analysis, independent t-tests, one-way ANOVA (analysis of variance), Pearson correlation coefficients, and hierarchical multiple regression. Results: Second-victim experience revealed a significant negative correlation with second-victim support and a significant positive correlation with negative work-related outcomes. The second-victim experience was found to be a significant predictor of negative work-related outcomes. These factors explained 46.3% of the negative work-related outcomes in the regression model. Conclusion: It is necessary to determine the degree of second-victim experience among clinical nurses and provide second-victim support to prevent future occurrences of negative work-related outcomes.