Background: Female smokers have different characteristics from male smokers; thus, this study investigated the factors related to the success of quitting smoking among female smokers. Methods: The study sample included 1,118 female smokers enrolled in the visiting smoking cessation program of a single regional smoking cessation center from June 1, 2015 to December 31, 2017. Data were provided by the National Tobacco Control Center. The success of smoking cessation for six months was confirmed through a urine cotinine test. Results: The smoking cessation success rate was higher among those aged over 40 years compared to other age groups. Total smoking duration (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.89–0.98), nicotine dependence (OR, 0.79; 95% CI, 0.69–0.91), and exhaled carbon monoxide concentration (OR, 0.96; 95% CI, 0.91–1.01) were negatively correlated with the six-month success rate. Confidence in quitting smoking at first counseling (OR, 1.21; 95% CI, 1.06–1.37) and total number of counseling sessions (OR, 1.51; 95% CI, 1.40–1.63) were positively correlated with the success rate of quitting smoking at six months. Conclusion: The six-month smoking cessation success of female smokers enrolled in the visiting smoking cessation program was associated with age of 40 years or older, having a short smoking period, low nicotine dependence, low carbon monoxide concentration, high smoking cessation confidence, and high number of counseling sessions.