As treatment options for the COVID-19 pandemic are limited, the most effective strategy so far is to obtain herd immunity through vaccination; however, the fear of adverse reactions following immunization is a detriment to this process. Considering that the risks of adverse reactions to the COVID-19 vaccine is very low, much of this fear is unsubstantiated. In order to alleviate this fear and properly identify high-risk populations, medical professionals should have a better understanding of the allergic reactions caused by the COVID-19 vaccine. People belonging to high risk groups should be assessed as to whether vaccination is possible and when necessary, receive treatment and close monitoring for adverse reactions following immunization.