With the new generation of information technology as the core of the rapid development of digital technology, digital technology is having profound impact on China's industrial structure. Based on 8 years of data from 2014 to 2021 from 30 provinces in China (excluding Hong Kong, Macao, Taiwan and Tibet), this paper adopts fixed-effect model and panel data to analyze the overall impact of the application and development of digital technology on the transformation and upgrading of industrial structure and regional heterogeneity. The main conclusions of this paper are as follows: The application and development of digital technology in China can promote the transformation and upgrading of industrial structure. The application and development of digital technology in China has a regional effect on the transformation and upgrading of industrial structure. The impact of the application and development of digital technology on the rationalization of industrial structure in China's three major economic regions is manifested in the western region> the central region > the eastern region; The impact on the transformation and upgrading of industrial structure in China's three major economic regions is manifested in the the central region > the eastern region>western region.