Background: Since the year 1978 continuous subcutaneous insulin infusion (CSII) became the best near-physiological way of insulin substitution. The purpose of this study was to answer these questions: 1) how many persons have been put on an insulin pump since 1995 2) how many of them rejected the insulin pump 3) how many of them were switched to another kind of treatment 4) how many of CSII-treated patients died Methods: The study was carried out in a diabetes center in the course of 18 years (1995-2012). Various types of insulin pumps were applied and upgraded shortly beyond the date of their 48-month expiration period. The indications for CSII were insuffi cient diabetes control, progression of complications, pregnancy and patient´s motivation. Results: A total of 580 patients (aged 11-78 years, 481 treated for T1DM and 99 persons for T2DM) were put on insulin pump in our center (n = 532) or referred with a pump to our center from a children`s department (n = 48) at their age of 18 years. A duration of diabetes varied from 0 to 56 years. Six patients (1%) rejected the pump within 6 years after insertion due to stress related to new technologies. Seven patients (1,2%) were switched to other treatment, three patients had to be switched to other treatment due to their low compliance. Twenty-six pump-treated patients (4,5%) died due to late renal failure (n = 5), myocardial infarction (n = 2), heart failure (n = 12), stroke (n = 2), pneumonia (n = 2), M.Alzheimer (n = 2) or unknown cause (n = 1). Conclusions: Growing numbers of persons with diabetes type 1 and type 2 put on insulin pumps demonstrate increasing motivation of patients in recent technology for diabetes treatment.