Objective : To identify of high-risk groups in endometrial carcinoma, we evaluate the prognostic significance of certain tumor biomarkers for cell proliferation(Ki-67) and cell-cycle regulation.(p53 and p21) Methods : 21 patients diagnosed with endometrial carcinoma between 1992 and 1999 in who were treated at Kyung Hee university medical center were studied. Using paraffin-embedded tumor tissue, immunohistochemical staining was done. Chi-square test was used to know the relationship between p53, p21, Ki-67 expression and clinicopathologic parameters and the relationship between p21 expression and p53, Ki-67 expression. Kaplan Meier survival analysis and log rank test were used to know the relationship between p53, p21, Ki-67 expression and patient's survival. Results : p53 and p21 expressions were seen in 52.4% and 85.7% of endometrial carcinoma. There were statistical significance only between p53 expression and poor histologic grade, lymphovascular space invasion and between Ki-67 expression and poor histologic grade, advanced stage. We could not find any relationship between p21 and p53 expression. Conclusion : Expression of p21 was not correlated with p53 expression. In the present study we suggested that p21 and Ki-67 expression could not be utilized as a good prognostic factor in endometrial carcinoma. p53 expression considered as a prognostic indicator in patients with endometrial carcinoma.