Case RePort : Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse
- Resource Type
- Article
- Authors
- Se Young Jang; Han Ik Bae; In Kyu Lee; Hwan Ki Park; Chang Min Cho
- Source
- Gut and Liver. Nov 30, 2015 9(6):805
- Subject
- Cholangiocarcinoma
Endoscopic ultrasound-guided fine needle aspiration
Individualized medicine
Xenograft
- Language
- English
- ISSN
- 1976-2283
Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic agents. We succeeded in generating a patient-derived tumor xenograft of a biliary tumor obtained by endoscopic ultrasound-guided fine-needle aspiration from a patient who had an inoperable extrahepatic cholangiocarcinoma. This patient-derived tumor xenograft will be a promising tool for individualized cancer therapy and can be used in developing new chemotherapeutic agents for the treatment of biliary cancer in the future. (Gut Liver 2015;9:805-808)