Ti and Ti-based alloys are widely used as biomaterials due to the combination of its outstanding characteristics such as high strength, low density (high specific strength), high immunity to corrosion, complete inertness to body environment, enhanced biocompatibility, low Young's modulus and excellent cell association with bone and other tissues. Nowadays, pure titanium and Ti-6Al-4V ELI(extra low interstitial) alloys are being applied for dental and orthopedic implants. In addition, their Young's modulus (approximately 50%) are less than Co-Cr and stainless steel biomaterials. So pure titanium and Ti-6Al-4V ELI alloys could help to reduce a stress shielding effect. However, Ti-6Al-4V ELI alloy for biomaterials has been suffered due to mismatch of Young’s modulus between the bone (2-20GPa) and this alloy (100-120GPa) and toxic elements in Ti-6Al-4V ELI alloy such as Al and V. Therefore pure Ti and Ti based biomaterials have non toxic elements and low Young's modulus than commercial Ti or Ti alloys. Porous Ti or Ti based biomaterials could be one of the methods to reduce the Young’s modulus. In this study, Ti-Nb-Zr alloy which is well known as low Young’s modulus alloy due to β-Ti phase and good biocompatibility due to non toxic elements, was used as based alloy. Furthermore, space holder method which is cost effctive process was used to fabricate porous Ti-Nb-Zr alloys. The size, distribution and shape of pore can be controlled in alloy addition of space holder with different size and shape, content. Generally, space holders such as NH4HCO3 would be evaporated during sintering by spontaneous reaction with heat. Therefore, to make a porous Ti-Nb-Zr alloys, powders of Ti, Nb and Zr, NH4HCO3 as space holder and TiH2 as foaming agent were used. And then sintering of the Ti-Nb-Zr-NH4HCO3 with TiH2 was progressed using with SPS after mixed and milled, respectively.In this study, Porous Ti-Nb-Zr biomaterials with space holder(NH4HCO3) and pore foaming agent(TiH2) were successfully fabricated by the SPS using high energy mechanical milled and mixed powders. The Young's modulus was lower than Ti-6Al-4V about 50 GPa by addition of 20wt% space holder. And Biocompatibility of Ti-Nb-Zr specimens was higher than Ti-6A-4V alloy. And biocompatibility were increased with increasing volume percent of space holder.