Natural phenolic compounds are distributed ubiquitously in plant tissues, including fruits and vegetables. The phenolic compounds have chemical structures having at least one aromatic ring with hydroxyl group. The physical and chemical properties depends on the structure of the phenolic molecules. For example, one of phenolic molecules catechol has strong intensity of adhesion on wet surface. The adhesive properties of these catecholic materials mainly depend on the configuration of the vicinal diol in the catechol ring, and the cohesive property of the catechol materials relies on the oxidation of catechol. Surface modification using DOPA-mimetic molecules is utilized in surface-initiated polymer grafting, cell adhesion, and patterning.In this study, we explain the application according to the characteristics and structure of phenolic compound by dividing it into two parts: adhesive and antioxidative effects.The first is coating on dental implant of phenolic compound using adhesive properties. Although Dipterocarpus tuberculatus Roxb. (MED), which contains a mixture of phenolic compounds is known for antioxidantive and anti-inflammatory effects, it has not been used for cell-adhesive materials. Herein, we newly consider the plant extract of MED to be a suitable surface coating material for promoting the osseointegration of Ti implants. Inspired by the outstanding adhesion performance of natural phenolic compounds on metal substrates, we coated a natural plant extract, MED on Titanium (Ti) implants. We tested three groups of Ti plates and screw-shaped fixtures: non-treated Ti, ozone-treated Ti as commercially used surface modification for dental implants, and MED-coated Ti. Interestingly, the MED coating on the Ti plate preserved the surface wetting property for 20 days, whereas the hydrophilic wetting of ozone-treated Ti was readily transformed to hydrophobic within a day. Computerized tomography and histopathological analysis revealed that MED coating enhanced new bone tissue formation and regeneration. The gene expression level of integrin as a bone cell adhesion receptor and its downstream key regulators was significantly increased than that of ozone-treated Ti. Therefore, we suggest considering MED-mediated cell signaling pathways in screening natural products for cell adhesion and osseointegration, and MED as a suitable coating agent for improving Ti implantation. The second is a development of an antioxidant drug delivery system using the antioxidant properties of phenolic compounds. At the molecular level, the correlation between single phenolic structure and antioxidant activity, and their effect on behaviors in cellular level has not been fully understood. Antioxidant drugs have been widely used for the purpose of preventing/treating cancer, the main cause of which is oxidative stress. In this study, the structure-antioxidant relationship was first investigated in order to coat the anti-cancer drug carrier with the most effective and stable antioxidant. By selecting an ideal antioxidant and coating it on polydiacetylene liposome, the effect of killing cancer cells was observed.