Although cancer has been major health problem worldwide and become the second leading cause of death, and current clinical cancer treatments are still limited to radiotherapy, chemotherapy and surgery. These approaches cause the risk of suffering side effects, such as systemic toxics, killing normal cells and an increased incidence of second cancers. To overcome these side effect of conventional tumor treatment. Many researchers have been focus on nanoparticles based anti-cancer drug delivery. However, the unacceptable targeting efficiency limits its clinical application. Ultimately result in less than 10% of the total administered dose being deposited in the tumor site. Herein, an advanced nanorobot system that mainly consists of electromagnetic actuation (EMA) system, near infrared red (NIR) light and magnetic nanocomposites based nanorobots were presented for cancer treatment.In this dissertation, 4 types of iron oxide based nanorobot candidates were fabricated by using thin film and hydration method or surface coating method. Then, Considering their biocompatibility, drug loading efficiency, light absorbance and magnetic property. The most promising nanorobot candidates were selected for the proposed nanorobot system. The nanorobot system exhibits excellent tumor targeting efficiency both in vitro and in vivo, using active actuation by EMA system, enhanced permeability and retention (EPR) effect and ligand-receptor mediated tumor targeting. Furthermore, an enhanced therapeutic effects can be achieved in the proposed nanorobot system by triggering drug release with NIR irradiation. Therefore, through the development of the proposed nanorobot system, the author believes that the dissertation has contributed to the strategy that can overcome the disadvantage of conventional cancer treatment or current anti-cancer drug delivery systems as well as has provided some solutions for developing clinically possible systems to treat cancer.