In this study, SiC nanopowders were coated on the surface of Ti6Al4V substrate through the laser cladding in air to improve the surface properties of Ti6Al4V alloy. The influence of laser parameters on the microstructure and mechanical properties of the coating was analyzed by energy dispersive spectrometry (EDS), optical microscopy, and scanning electron microscope (SEM). It was confirmed that the microstructure of the laser-clad coating can be divided into two layers. The upper layer was an oxide layer with a large amount of oxygen, and the lower layer was a reaction layer with the titanium substrate. The hardness of the reaction layer was measured with a Vickers hardness tester. As the laser scanning speed increased, the hardness of the coating increased. When the scanning speed reached 5 mm/s, the maximum hardness was 980 HV, which was more than three times at the Ti substrate. The wear resistance and friction of the coating surface were also significantly improved after the laser cladding. Due to the influence of the oxide phases, the friction coefficient was reduced more than 80%.