Purpose: Self-efficacy is a crucial factor of self-management in cancer patients. The purpose of this study was to examine the relationship between health literacy, social support, and self-efficacy outcomes in cancer patients. Method: The participants were 130 cancer patients admitted to a hospital in daegu for cancer treatment. Data were collected using a self-report questionnaire from August to October 2023. The data were analyzed using descripitive statistics, independent t-test, one-way ANOVA, Pearson’s correlation coefficients with IBM SPSS 29.0 program. After controlling for general characteristics that were significant in univariate analysis, the relationship between health literacy, social support, and self-efficacy was confirmed using partial correlation. Results: As a result of Self-efficacy was correlated with health literacy (r=.78, p