Compared with monolayer nanosheet membranes, multilayer nanosheet membranes have low energyconsumption and can be mass-produced for industrial applications. Herein, a multi-layer nanostructuredmembrane, nickel-doped brochantite/Cu(OH)2 nano protrusion structure coated copper meshes(NBCPCMs), were successfully prepared. Firstly, the surface of the copper mesh was etched by chemicaloxidation to form a disordered copper hydroxide nanosheet layer. Secondly, the etched copper mesh surfacewas coated with nickel-controlled brochantite block-like protrusions by hydrothermal synthesismethod, and nickel-doped brochantite/Cu(OH)2 nanosheets were generated by high pressure. The resultsshowed that NBCPCM-4 had excellent hydrophilic/underwater superoleophobicity, the oil–water separationefficiency of immiscible cyclohexane/water mixture was the highest, about 98.54%, and still had avery high flux (>60 (kL/(hm2))) after multiple cycles of separation. In addition to ultra-high separationefficiency, NBCPCM-4 also had super durability. The copper mesh maintained good underwater superoleophobicityin different aqueous solutions. Therefore, NBCPCM-4 is a potential high-efficiency and sustainableoil–water separation membrane material. It is expected that the developed technology is usefulfor sea transportation and marine environment management, along with other industries.