The semi-solid A380 aluminum alloy slurry prepared by water-cooling serpentine channel and its rheo-diecasting werestudied in this paper. The result showed that the pouring temperature and cooling water fow rate had a signifcant efect onthe semi-solid slurry. When the pouring temperature decreased from 670 to 610 °C, the average grain diameter and shapefactor of the primary α-Al grains decreased from 64 to 47 µm and increased from 0.74 to 0.82, respectively, but the mass ofsemi-solid slurry blocked in channel increased. With the cooling water fow rate increasing from 0 to 1000 L/h, the semisolid slurry frstly got optimized and then deteriorated. Under the condition of the same die casting process parameters, therheo-diecastings produced by the semi-solid slurry prepared through water-cooled serpentine channel had higher mechanicalproperties than those of the traditional die castings.