Blast furnace slag (BFS), as a byproduct from manufacturing iron, served as a cost-effective raw materialfor preparation of hydroxyapatite-zeolite composite material (HAP-ZE); this research introduces a way ofsynthesizing hydroxyapatite-zeolite composite material (HAP-ZE) using BFS with alkaline fusion andhydrothermal treatment. According to analysis with XRD, FT-IR, BET, ICP, FE-SEM, EDX and elementalmapping, the major phases in the HAP-ZE composite material synthesized under the most desirable conditions(at aging time of 6 h and at Ca/P ratio (starting gel) = 1.67) were identified to be zeolite and HAPwith molar ratio of Ca/P = 1.61, Si/Al = 1.31, Na/Al = 1.75 and with a mean surface area of 44.22 m2.g 1. Moreover, the research found that the minor metals (Mg, Fe, K, etc.) generated from BFS have little influenceon the synthesis of HAP-ZE. The thus obtained HAP-ZE material has a great adsorption performancein removing Mn2+, NH4 + and phosphate ions mixed in water, on grounds of the higher ion-exchange capacitiesand abundantly existing Ca2+ ions in HAP-ZE structure. This novel process makes synthesizing HAPZEcomposite material from BFS possible and lays a great foundation for effective application of BFS.