The antihypertensive activity of few-flower wildrice was studied in spontaneously hypertensive rats (SHRs)with evaluation of blood pressure lowering effects andtranscriptional levels of the sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) gene that is regulated by AngiotensinII (Ang II). SHRs were randomly divided into 5 groupswith 6 rats each. The systolic blood pressure (SBP) reachedthe lowest point 3 h after administration of a single dose ofpaste made from few-flower wild rice stem powder. TheSBP of SHR in the relatively high amount of RSP (HRSP)administrated group was reduced by approximately 30mmHg, compared to the negative control group, and wasnot significantly different from the positive control IPPcontrol group at a dose of 1.5 mg/kg body weight (p>0.05). RSP administrated SHRs showed a significantly higherSERCA2a transcription level than negative control SHRs(p<0.05). RSP administration had no negative effects onglycometabolism of SHR.