A 7-year-old spayed female Welsh corgi presented with a mass of the skull. The mass was diagnosed asmultilobular bone tumor and surgically removed. To treat a large bone defect after the tumor removal, custom-madeartificial bone fabricated by a 3-dimensional ink-jet printer was implanted in the defect. Follow-up computed tomographyevaluation was performed for 4.3 years. The implant was well integrated with the skull and had covered the largebone defect during the follow-up period. Gradual degradation of the implant began 6 weeks after surgery. It providesan additional option for the treatment of large bone defect.