The boundary layer heat transfer and entropy generation of a nanofluid over an isothermal linear stretching sheet with heat genera-tion/absorption have been analyzed. In the nanofluid model, the development of nanoparticles concentration gradient due to slip mecha-nisms, the effects of Brownian motion and thermophoresis, are taken into account. The dependency of the local Nusselt number and entropy generation number on the non-dimensional parameters is numerically investigated. The results show that the increase of heat generation parameter, Brownian motion parameter, or thermophoresis parameter decreases the entropy generation number in the vicinity of the sheet.