Cancer remains to be a major challenge for public health providers, and is the second leading cause of death worldwide. Therefore,it is imperative to explore the mechanisms underlying cancer initiation and development, and design novel diagnostics andtherapeutics. Circular RNAs (circRNAs), which exhibit a covalently closed loop structure, are involved in a variety of diseases, includingcancer. The aberrant expression of circRNAs contributes to the initiation and development of various cancers by disruptingthe interplay of specific signaling pathways, including the Wnt/β-catenin pathway, which controls a plethora of cellular processesthat drive cancer development. The interactions between circRNAs (specifically expressed in different cancer tissues) andWnt/β-catenin signaling pathway presents potential diagnostic biomarkers and novel therapeutic targets. In this review, we havesummarized research discoveries on the functions of Wnt/β-catenin pathway-related circRNAs in the modulation of oncogenesisand progression of different types of cancer. We anticipate that our findings will contribute to the improvement or developmentof circRNAs-based strategies for cancer treatment.