Hot processing maps have been widely used to reveal the relationship between microstructures and final performances ofAl–Li alloys after deformation. However, there are few researches on the hot processing maps of 1460 Al–Li alloy. In thispaper, the safe zones were identified based on the corrected data with temperatures range from 300 to 500 °C and strain ratesrange from 0.001 to 10 s−1. Then, the microstructural characteristics and corresponding dynamic softening mechanismswere systematically investigated by employing various characterization methods. The optimum domains were establishedat 300–500 °C/0.001–0.01 s−1 dominated by continuous dynamic recrystallization and dynamic recovery, while cracks werefound when temperatures set around 450 °C with the highest power dissipation efficiency value of 55%. Flow localizationsand micro-shear bands were also observed in instable domains of low temperature (< 400 °C) and low strain rates (< 0.1 s−1)with lower power dissipation efficiencies (< 10%), then disappeared as temperature increased and strain rate decreased. T1precipitate bands are developed in these micro-shear bands inside grains and provide pinning pressure on dislocation movements,impeding dynamic recovery and recrystallization processes, which is expected to be an effective way to refine grainsand enhance mechanical properties. These findings can better optimize the processing parameters of this alloy and furtherexpand its application field.