Oxidative stress and hypogonadism are linked to the increased incidence of cardiovascular disease in males.The objective of this research was to delineate whether drinking cranberry juice for 4 months affects antioxidant capacity andlipid profile in orchidectomized rats. Thirty-two 1-year-old male rats were randomized to two groups: a sham-control group(n . 8) and an orchidectomized group (n . 24). The orchidectomized group was divided into three groups of eight and as-cranberry juice. At 120 days after initiation of the study, all rats were killed, blood was collected, and plasma was harvestedfor total antioxidant status, malondialdehyde, nitrate. nitrite, and superoxide dismutase (SOD) activity in liver, and concen-trations of cholesterol and triglyceride in liver and in plasma. Orchidectomy depressed (P. .05) plasma antioxidant capac-ity and SOD activity, elevated (P. .05) nitrate. nitrite and malondialdehyde in plasma, and increased (P. .05) triglycerideand cholesterol values in liver and in plasma. Cranberry juice increased (P. .05) plasma antioxidant capacity and SOD ac-P. .05) nitrate. nitrite and malondialdehyde concentrations. Drinking cranberry juice did not affect cho-lesterol concentrations in liver and in plasma. Triglyceride concentration in plasma of orchidectomized rats that were drink-ing cranberry juice increased (P. .05), but its concentration in liver decreased (P. .05) to the level of shams. The protectiveeffect of cranberry juice from oxidative damage may be mediated by a decrease in nitrate. nitrite and dose-dependent de-crease in peroxidation.