A Novel Nasal Delivery System of a Chinese Traditional Medicine, Radix Bupleuri, Based on the Concept of Ion-Activated in Situ Gel
- Resource Type
- Article
- Authors
- Shi-Lei Cao; En Chen; Qi-Zhi Zhang; Xin-Guo Jiang
- Source
- Archives of Pharmacal Research, 30(8), pp.1014-1019 Aug, 2007
- Subject
- 약학
- Language
- ISSN
- 1976-3786
0253-6269
The purpose of this study was to develop a nasal in situ gel system for Radix Bupleuri employing gellan gum as a polymer. Radix Bupleuri in situ gel containing 0.2 mL essential oil extracted from 450 g Radix Bupleuri, proper solubilizing agents and gellan gum (0.5% w/v) was prepared and characterized. The antipyretic effect produced by in situ gel formulation was investigated in fevered rabbits and compared to an intranasal solution. The resulting in situ gel was a clear and light-yellow liquid, with viscosity of 346 mPa·s and caproic acid content of 1.31± 0.01 mg/mL. Intranasal administration of this preparation to fevered rabbits decreased body temperature markedly (1.1oC at the doses of oil from 1.5 g Bupleuri/body) and the effect could last for 20-30 h. The results suggest that Radix Bupleuri in situ gel can be greater effective than the solution in the treatment of fever.