High entropy alloys (HEAs) have received tremendous attention in diferent applications because of their excellent corrosion resistance and superior mechanical properties. In the present work, a novel TiNbMoMnFe high entropy alloy systemwas synthesized and deposited on AISI 316L by DC magnetron sputtering system. The microstructure of the resulting thinflm was evaluated by grazing incidence X-ray difraction and feld emission electron microscope. It was found that the thinflm microstructure is composed of a crystalline solid solution (grain size of 76 nm) and an amorphous phase. The electrochemical investigations in Ringer’s solution revealed that a thin flm of 670 nm thick high entropy alloy has a low corrosioncurrent density of 0.024 μA cm−2, approximately 30% lower than that of the uncoated 316L. Meanwhile, the HEA thin flmshowed the highest pitting corrosion resistance and stability of the passive flm. The wettability examinations exhibited thatthe coated sample has a high contact angle of 90° in contrast to 60° for the uncoated ones. In summary, the TiNbMoMnFehigh entropy alloy thin flm shows great potential for use in biomaterial applications.