Vitamin E is known to improve antioxidant status and to prevent lipoprotein oxidation. However, the effectof vitamin E on other cardiovascular risk factors, including C-reactive protein (CRP) and lipid profile status, in orchiectomizedrats is unknown. In the present study, 32 1-year-old male rats were randomized into two groups: a sham-control group (n .8) and an orchiectomized group (n . 24). The orchiectomized group was divided into three groups of eight and assigned toone of the following treatments: orchiectomy (ORX), ORX . vitamin E mixture (65.6 mg/kg) diet, or ORX . vitamin Emixture (656 mg/kg) diet. For 120 days all four groups consumed a basal AIN-93M diet, while the vitamin E groups ate di-ets containing an additional vitamin E mixture. Four months after the study began, all the rats were killed, the blood was col-lected, and the plasma was assayed for antioxidant status, CRP, lipid profile, and indices of peroxidation. ORX decreased(P. .05) the plasma antioxidant status, superoxide dismutase (SOD) activity, and CRP level and increased (P. .05) theplasma malondialdeyde, nitrite, and lipid profile compared with that of the sham-control group. In contrast to the ORX group,supplementation with vitamin E mixture increased (P. .05) plasma antioxidant status and dose-dependently increased (P..05) SOD activity, while the vitamin E decreased (P. .05) plasma malondialdeyde and nitrite. The vitamin E mixture hadno effect on CRP or on lipid profiles when compared to the orchiectomized rats. In conclusion, vitamin E appears to reduceoxidative stress without modulating lipid profile or inflammatory response.