Novel N-(2,2′-disubstituted-2H-cromenyl)-N′,N″-disubstituted Guanidine Derivatives as an S-Nitrosoglutathion Reductase Inhibitor
- Resource Type
- Article
- Authors
- 이기형; 남연주; 김은미; 임수정; 양승주; 박규희; 최용문; 공영대
- Source
- Bulletin of the Korean Chemical Society, 36(9), pp.2224-2229 Sep, 2015
- Subject
- 화학
- Language
- English
- ISSN
- 1229-5949
0253-2964
Novel N-(2,2′-disubstituted-2H-cromenyl)-N′N″-disubstituted guanidine derivatives were synthesized and evaluated as an S-nitrosoglutathion (GSNO) reductase inhibitor. The synthesized guanidine derivatives 1 and 2b showed high potency in an enzyme-based assay with recombinant GSNO reductase (IC50 < 10 μM). Surface plasmon resonance measurement and molecular docking studies confirmed the direct interaction of compound 2b with GSNO reductase. The results provide valuable information for the design of inhibitors with better spectrum of activity toward GSNO reductase.