This study aims to gain the design data through the process design of the organic Rankine cycle, which can produce 250kW of electric power through waste heat recovery. In this study, a simulation was conducted using APSEN HYSYS to make the model for the process design of the 250kW-class waste heat recovery system. For the thermodynamic model, the test was conducted with hot water as the heat source, the water steam as the cooling water for the cooler, and the refrigerant R245FA in the cycle. In the final design, it was expected and found from the simulation that the cycle efficiency was 12.62% and that 250kW of power was produced considering the margin of 80%.