A 51-year-old female with idiopathic portal hypertention (IPH) was admitted to our hospital with complaints of hematemesis and tarry stool. Emergent esophagogas-troduodenoscopy revealed varices in the second portion of the duodenum, on the top of which a fibrin plug was demonstrated. From this finding, rupture of duodenal varices was confirmed. The varices were treated twice by endoscopic injection sclerotherapy (EIS) with N-butyl-2-cyanoacrylate (Histoacryl). After EIS, no further bleeding occurred. Her clinical course was uneventful without any significant complications related to this the-apy.