Two cases of decompensate liver cirrhosis (alcoholic and HBV) with hypersplenism, who were rescued from liver failure with massive ascites by splenectomy, were reported. According to previous clinical and experimental reports, partial splenic embolization or splenectomy could improve liver function as well as pancytopenia in patients with liver cirrhosis with hypersplenism. Splenectomy could be considered for patients with decompensate liver cirrhosis who can not get a donor for living donor liver transplantation. However, attention should be paid for patients with hepatocellular carcinoma or any viruses since the effect of splenectomy on cancer or virus is unknown.