In recent years, the importance of intraoperative navigation in ENT surgery has been increasing. Multiple studies have proven the advantages and safety of computer-assisted lateral skull base surgery. Herein, we report on the feasibility and usefulness of the StealthStation® navigation system in combination with the O-arm® system for the resection of temporal bone tumors. The technical details, setting of the operating room, advantages, and limits of the method have also been described. From our overall impression, the O-arm-StealthStation navigation system provides some sense of security and confidence to surgeons and may be successfully extended to various types of temporal bone surgeries.