The subject was a 65-year-old female patient with chief complaints of a sore throat and cervical swelling. Obstruction of the airway was observed and endotracheal intubation was carried out as an ambulatory service. CT revealed a left peritonsillar abscess and deep cervical abscess, along with an abscessed lesion developing continuously in the mediastinal direction up to the bifurcation of the trachea. A cervical incision and drainage were conducted the same day. The mediastinal abscess remained, however. Despite conducting another cervical incision, we could not achieve drainage from the mediastinum. During the course of the operation, the abscess further enlarged and the general condition of the patient deteriorated. An esophageal intramural abscess was suspected from the findings. Upon consultation with the Department of Gastrointestinal Surgery, an esophageal submucosal abscess was suspected. We then made an incision under endoscopy, resulting in a large amount of drainage, after which the general condition of the patient rapidly improved.