This paper deals with effective weekly paclitaxel + 5'-DFUR therapy for advanced breast cancer refractory to CAF and surgical therapy. A 37-year-old woman was admitted to the department because of right breast tumor with a vertebral tumor. Histological examination revealed breast cancer with bone metastasis. Modified radical mastectomy after 3 courses of CAF therapy was performed. One course of CAF therapy was added after the operation, but a tumor marker continued to increase. The weekly paclitaxel + 5'-DFUR therapy was therefore initiated. After this chemotherapeutic regimen, a marked decrease of tumor marker was observed. No major adverse reactions to this chemotherapy were observed, and good patient's QOL was achieved. Based on these findings, this chemotherapeutic regimen appears to be a new effective treatment for advanced breast cancer.