Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN) is a non-pharmacologic treatment for cancer pain and an optional measure when adequate control with pharmacologic therapy is difficult. EUS-CPN techniques include the central method (CI) in which puncture and injection are performed at the origin of the celiac artery, the bilateral injection (BI) method approaching both sides of the celiac artery, and celiac ganglia neurolysis (CGN) in which puncture and injection are performed directly in the celiac ganglia. Clinical studies and meta-analyses have supported the safety, pain relief, opioid reduction, and quality of life benefits of all three techniques. However, the optimal choice of technique remains debated and should be evaluated in well-designed randomized controlled trials. Recently, radiofrequency ablation (EUS-RFA) and radioactive seed implantation in the celiac ganglia have been reported as an extension of EUS-CPN. These new techniques have been reported only in a few cases, so more extensive studies are needed in future.