Purpose: To evaluate the feasibility and efficacy of hybrid therapy in patients with peripheral arterial disease.Materials and methods: Between April 2009 and November 2012, 15 patients (15 limbs) with peripheral arterial disease underwent hybrid therapy. The patients comprised 10 men and 5 women, with an average age of 79 years. Technical success rate, clinical success rates, patency rates, incidence of postoperative complications, and any additional therapy were evaluated.Results: Technical success rates were 100%. Clinical success rates were 86%. Mean ABI at rest increased significantly from 0.35±0.29 to 0.84±0.21 (p < 0.05). With a mean follow-up period of 477 days, the 1-year primary patency rate was 90%. One patient died of acute renal failure after hybrid therapy. One patient underwent secondary intervention.Conclusion: Hybrid procedures are often useful for treatment of patients with peripheral arterial disease having multilevel lesions and complex problem.