Target Protein-Oriented Isolations for Chemical Biology based on Natural Products / 標的タンパク質指向型天然物単離による天然物ケミカルバイオロジー
- Resource Type
- Journal Article
- Authors
- Masami Ishibashi; Midori A. Arai; 石橋 正己; 荒井 緑
- Source
- 有機合成化学協会誌 / Journal of Synthetic Organic Chemistry, Japan. 2021, 79(7):684
- Subject
- cancer cells
natural products
neural stem cells
protein beads
protein plates
- Language
- Japanese
- ISSN
- 0037-9980
1883-6526
Natural products have contributed to development of medicine for a long time. The structures and bioactivities of natural products often exceed the human knowledge and imagination. We have developed target protein-oriented natural products isolation methods to quick find bioactive compounds from natural resources (compounds mixture). This review summarizes our recent results including protein beads methods and protein plate method for neural stem cells differentiation activators and new cancer drug candidates. Isolated compounds accelerated neural stem cells differentiation and/or showed cytotoxicity against cancer cells. Syntheses of isolated compounds were also described. As protein binding ability tightly related bioactivity, protein based natural products isolation would be a powerful way to find new candidate of medicines.