A 4-year-old male setter dog weighing 20 kg with depression, intermittent severe generalized seizure and circling to the left, was neurologically revealed to have exaggerated reflexes of both patellar tendons and elevated protein content and total cell count in the cerebrospinal fluid (CSF). The CSF Pandy's test was positive, and magnetic resonance images demonstrated an irregular shaped mass, approximately 30 mm in diameter, in the left forebrain. The surgically removed mass histopathologically consisted of proliferated small spindle-shaped cells with whorl arrangement and occasional psammoma bodies, and was diagnosed as meningioma. The case was getting better, but he died of status epilepsy 5 months after the operation.