This study was carried out to clarify the incidence and clinical features of the patients with pancreatolithiasis experienced in Hokuriku district, Toyama, Ishikawa and Fukui prefectures, during the past seven years.Twenty-five out of 31 patients with pancreatolithiasis were males and six were females. The average age was 45.9 years old for men and 49.5 for women. The period from the appearance of initial symptoms to the time of the diagnosis were less than 3 years in 64.5per cent of the patients. This suggests that the calcification in the pancreas appeared relatively in shorter period than generally considered. Ninety-four per cent of 31 patients complained of an abdominal pain but seven per cent had no pain. Etiologically, 48.4per cent were regarded as being related to alcohol intake, 9.4per cent to biliary diseases, 3.2per cent to acute pancreatitis, but 38.7per cent could not be etiologically distinguished, (idiopathic form). Eighty-four per cent of the patients showed a functional insufficiency in the pancreatic exocrine and 71.4per cent showed also a disturbed endocrine function. Furthermore, the patients with a diffuse calcification in the pancreas showed a remarkable reduction in both of exocrine and endocrine functions, while four patients with a localized calcification had normal exocrine functions.From these results, it is presumed that the pancreatolithiasis does not always imply a final stage of chronic pancreatitis.