Cyflumetofen is a novel benzoylacetonitile acaricide developed by Otsuka AgriTechno Co., Ltd. It has excellent efficacy against a variety of mites that attack fruits, nuts, vegetables, tea, and ornamentals. In addition, cyflumetofen exhibited long persistence efficacy against mites. The new and unique chemistry of cyflumetofen provides effectiveness against mites that have developed resistance to existing acaricides. Extensive studies have shown that cyflumetofen inhibits the mitochondrial electron-transport function of complex II, which is a novel target for the mode of action among pesticides. These findings suggest that cyflumetofen could be an ideal component for integrated pest management (IPM) programs and resistant management programs because it is significantly safe for non-target organisms such as natural enemies and beneficial arthropods, and for the environment.