A sensitivity analysis for coupling parameters of mathematical model of pacemaker activity in the small intestine / 小腸ペースメーカモデルにおける結合パラメータに関する感度分析
- Resource Type
- Journal Article
- Authors
- Hideyoshi Ko; 高 英聖
- Source
- 生体医工学 / Transactions of Japanese Society for Medical and Biological Engineering. 2016, 54Annual(27PM-Abstract):230
- Subject
- Language
- Japanese
- ISSN
- 1347-443X
1881-4379
Slow wave and its propagation play an important role in regulating motility in the small intestine. A simple mathematical model based on the hypothesis about the interaction between autonomous oscillation in Interstitial Cells of Cajal (ICCs) and signal transfer in intestinal longitudinal muscle(LM) cells has already been proposed(Aliev et al.) and widely used. However, the detailed mechanism of pacemaker activity in this model - also in the small intestine - still remains unclear. In this study, a sensitivity analysis for coupling parameters in the ICC/LM network was demonstrated by numerical simulation to elucidate the dynamics of the intestinal pacemaker activity. Aliev's PDE model with two independent variables time t and position x was discretized in the x direction and solved numerically. Synchronicity and stability were evaluated from the periods of each oscillation. The results showed LM cells were essential for ICCs to oscillate synchronously with multiple frequency plateaus.