Viscoelasticity Determines the Property of Hydrogels as a Scaffold for 3D Culture of Cells / 三次元細胞環境としての機能性ハイドロゲルを用いた硬さと細胞応答に関する研究
- Resource Type
- Journal Article
- Authors
- Hidenori OTSUKA; Kazuki KUDO; Shigehito OSAWA; Shohei ISHIKAWA; 大塚 英典; 大澤 重仁; 工藤 和樹; 石川 昇平
- Source
- 色材協会誌 / Journal of the Japan Society of Colour Material. 2020, 93(11):343
- Subject
- Hydrogel
Proliferation and differentiation
Tissue engineering
Viscoelasticity
Young's modulus
ハイドロゲル
ヤング率
増殖分化
粘弾性
組織工学
- Language
- Japanese
- ISSN
- 0010-180X
1883-2199
Hydrogels have been utilized to design cell culturing scaffolds because they have a high potency to mimic biological environments due to their high water content. Viscoelasticity of the hydrogels has been reported to largely affect properties including differentiation and extracellular matrix formation of cells cultured in them. In practical use, biodegradable hydrogels, which continuously decrease the viscoelasticity, are highly demanded and installation of the biodegradability has been reported to improve the cells properties; however it is still unclear how cells respond to dynamic viscoelasticity change. Elucidation of this issue would promote future scaffold design and also tissue formation theory from cells.