The HSCD has been expected to increase the solute clearance with only a minimal disturbance in the circulatory function. Its clinical application, however, was restricted because of the abnormal sodium balance induced by the its continuous use. We made a concentration-controllable sodium infuser, DKJ-11 (NIKKISO), and have used it as a delivery system of additional dialyzate sodium in the HSCD. This paper is to evaluate the HSCD with the new infuser.The measured dialyzate sodium concentrations closely correlated with their theoretically expected values (r=0.991, p<0.001). In spite of the removal of about 4 liters of body fluid by this method, it was shown that hypotensive episodes were reduced to 15% and the range of serum sodium concentration at the end of dialysis was 139-142mEq/L, resulting in less magnitude of thirst. These results indicate a beneficial effect of the HSCD with this infuser by means of serial change in the dialyzate sodium concentration.