【Background】The treatments of malignant biliary and duodenal obstruction include surgical therapy or endoscopic therapy, and radiological intervention. Recently, double stenting, involving combined placement of a biliary stent (BS) and a duodenal stent (DS), has been reported as a low-invasive treatment. The appropriate therapy must be selected taking into consideration the patient’s prognosis, the timing of the duodenal obstruction, and the stenosis site. [Results] In all 16 patients, endoscopic double stenting (EDS) was performed safely with no early complications. The median DuS and BS patency period from the completion of the EDS were 40 days and 46 days. Furthermore, in the present study, we used two biliary drainage methods, ERCP and EUS-guided biliary drainage (EUS-BD). There were no differences in the success rate, complication rate, or the stent patency between the two methods. [Conclusion] EDS by ERCP and EUS-BD conducted in the present study was feasible and useful for the treatment of malignant biliary and duodenal obstruction.