In this study, we established basic guidelines for the design of compression running tights (Cp-type tights) with low physiological load. Three types of trial Cp-type tights which were the standing, knee bending and taping patterns were tested with seven female participants in their 20s. Bare feet were used as a control. They were asked to run at a speed of 7 km/h on a treadmill for 30 min. Electromyogram (EMG) and electrocardiogram (ECG) were measured during the experiment. EMG analysis involved the assessment of integrated EMG (iEMG). The iEMG decreased and the mean power frequency of EMG increased when wearing the Cp-type tights with the knee-bending (sample K) and taping (sample T) patterns. The sympathetic nervous activity obtained from ECG also tended to be low when wearing sample K.In subjective feeling, sample T was evaluated to suppress vibration in the thigh and lower leg muscles, and sample K was easier to put on and enabled easy bending of knees. These results suggest that it is important to apply the knee-bending pattern as well as local pressure to the legs by using taping for the design of Cp-type tights for a body load reducing effect. However, it is necessary to design the clothing such that the pressure around the inside of the lower legs is not high enough to interrupt muscle contraction.