Chronic limb-threatening ischemia (CLTI) is a clinical syndrome associated with increased mortality, risk of amputation, and impaired quality of life. To treat patients with CLTI appropriately, a multidisciplinary approach should be adopted. Holistic nursing, in particular, is important in the care and healing of foot wounds caused by ischemia and foot infection in these patients. In this setting, the role of specific nurses is expanded significantly to allow them to perform advanced practice under comprehensive instructions for timely wound assessment and foot care in collaboration with the nursing and medical teams. Daily practice conducted by a specific nurse, including educating and motivating patients, is subjective and should consider the patient’s own appraisal. Their perspectives contribute to multidisciplinary cooperation in CLTI treatment and help to develop ideal foot management to facilitate a smooth transition from inpatient to home care. This review provides practical content on the treatment of patients with CLTI.