Regulation of osteoclast differentiation by β-glucan mediated by dectin-1 recognition and pharmacological application / dectin-1受容体の認識を介したβ-glucanによる破骨細胞分化の制御と薬物療法の可能性
- Resource Type
- Journal Article
- Authors
- WATARU ARIYOSHI; 有吉 渉
- Source
- 歯科薬物療法 / ORAL THERAPEUTICS AND PHARMACOLOGY. 2022, 41(1):11
- Subject
- dectin-1
osteoclast
pattern recognition receptor
β-glucan
β-グルカン
デクチン-1
パターン認識受容体
破骨細胞
- Language
- Japanese
- ISSN
- 0288-1012
1884-4928
Coordinated co-stimulatory signals mediated by several immunoreceptors are important for the regulation of osteoclast differentiation. Dectin-1 is one of the pattern recognition receptors of β-glucan and is expressed on the surface of hematopoietic osteoclast precursor cells. In this review, we discuss the biological effects of β-glucans on bone-resorbing osteoclasts. Several β-glucans negatively regulate osteoclast differentiation by binding to dectin-1. Furthermore, we demonstrated the possibility of β-glucan as a candidate of osteoclast-targeting gene delivery system. Future studies concerning the relationship between the β-glucan structure and its biological effects on osteoclast are required for the development of novel pharmacological treatment for bone-related diseases.