Objective: The purpose of this study was to examine the role and characteristics of patient safety education using e-learning. Methods: A systematic review was conducted for the literature in PubMed, and 119 literature was obtained. Results: The amount of literature had increased over time (p=0.01), and the literature of systematic reviews or meta-analysis had increased since 2010. About half of the literature were education for physicians or nurses. In addition to the education of aiming the improvement of knowledge and skills, the literature aimed at improving attitudes such as patient safety culture has been recognized since 2016. Conclusions: Although a survey using published literature does not always reflect the current situation of education, the patient safety education using e-learning tended to increase with the growing interest in patient safety and the availability of e-learning methods, and the target may be expanding from physicians or nurses to other healthcare staff including medical students and nurse students. In the verification of the educational effect, it was considered necessary to create a mechanism that enables evaluation of the actual contribution of patient safety using outcomes such as the number of adverse events and errors.