Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors
- Resource Type
- research-article
- Authors
- Bonardi, Vera; Tang, Saijun; Stallmann, Anna; Roberts, Melinda; Cherkis, Karen; Dangl, Jeffery L.
- Source
- Proceedings of the National Academy of Sciences of the United States of America, 2011 Sep . 108(39), 16463-16468.
- Subject
- Pathogens
Leaves
Proteins
Receptors
Cell death
Phenotypes
Gene expression regulation
Infections
Plant immunity
Seedlings
- Language
- English
- ISSN
- 00278424
Plants and animals deploy intracellular immune receptors that perceive specific pathogen effector proteins and microbial products delivered into the host cell. We demonstrate that the ADR1 family of Arabidopsis nucleotide-binding leucine-rich repeat (NBLRR) receptors regulates accumulation of the defense hormone salicylic acid during three different types of immune response: (i) ADRs are required as "helper NB-LRRs" to transduce signals downstream of specific NB-LRR receptor activation during effector-triggered immunity; (ii) ADRs are required for basal defense against virulent pathogens; and (iii) ADRs regulate microbial-associated molecular pattern-dependent salicylic acid accumulation induced by infection with a disarmed pathogen. Remarkably, these functions do not require an intact P-loop motif for at least one ADR1 family member. Our results suggest that some NB-LRR proteins can serve additional functions beyond canonical, P-loop-dependent activation by specific virulence effectors, extending analogies between intracellular innate immune receptor function from plants and animals.