The purpose of this study is to investigate the relationship of grit with well-being and self-efficacy. Grit was considered as a two-factor variable with consistency of interest and perseverance of effort. For the empirical analysis, data were collected from the sample of 237 nurses working at general hospitals. Collected data were analyzed using SPSS 26 to test the hypothetical relationships. It was suggested that two factors of grit would be possible associated with well-being. However, the results of this study showed that the consistency of interest part of grit had non-significant effect on well-being, Perseverance of effort part of grit had indirect effect on well-being through fully mediation effect of self-efficacy. This study confirmed that grit, some how, positively related to well-being and variables such as ,self-efficacy, could be a important variable to bridge grit to well-being. Further studies were suggested to perform studies on more about grit’s two factors and unexplored external variables between grit and well-being of nursing professionals.