The purpose of this study was to investigate how depression and the presence of meaning in life affect warning symptoms of relapse in alcoholics. The data were collected from 270 alcoholic inpatients who were treated in an alcohol hospital located in a metropolitan city of South Korea over three months between November 2019 and January 2020 and analyzed by descriptive statistical analysis, t-test, ANOVA, Pearson correlation coefficient, hierarchical regression and structural equation. Bootstrapping was performed to confirm the significance of indirect effects of mediating parameters. The results of this study showed significant correlations among depression, the presence of meaning in life, and warning symptoms of relapse in alcoholics. The presence of meaning in life showed a significantly negative correlation with depression and warning symptoms of relapse in alcoholics, and partially mediated the relationship between depression and warning of relapse in alcoholics. The findings suggested further research studies to prevent relapse in alcoholics.